A multicentre randomised phase III trial comparing atezolizumab plus bevacizumab and standard chemotherapy versus bevacizumab and standard chemotherapy as first-line treatment for advanced malignant pleural mesothelioma

BEAT-meso: BEvacizumab and ATezolizumab in malignant pleural mesothelioma

Chemotherapy with cisplatin plus pemetrexed is the currently approved standard as first-line therapy for patients with malignant pleural mesothelioma. The best survival outcome to date has been achieved by combining standard chemotherapy with bevacizumab. However, new treatment strategies are needed in order to further improve outcome. Immunotherapy has achieved promising results in a subset of patients with PD-L1-positive tumours in the second-line setting.

The aim of the BEAT-meso trial is to address whether the addition of the anti-PD-L1 antibody atezolizumab given in combination with standard chemotherapy plus bevacizumab improves the outcome in advanced treatment-naïve malignant pleural mesothelioma patients.

Trial Scheme

ETOP 13 18 BEAT meso Trial Scheme


Primary Endpoint: Overall survival
Secondary Endpoints:

Progression-free survival (investigator assessed)

Objective Response rate

Disease control rate

Time to treatment failure

Duration of response

Safety and tolerability

Patient reported outcome

Quality of life

Target Sample Size: 400 randomised patients
Protocol Release Date: 7 September 2018
Trial Activation Date: 12 April 2019
First Patient In: 30 April 2019
Accrual Closure Date: 07 March 2022

Trial Organisation

Trial Chair: Enriqueta Felip
Trial Co-Chair: Sanjay Popat
Sponsor: ETOP IBCSG Partners
Coordinating Group: ETOP IBCSG Partners
Participating Groups: SAKK and SLCG
Participating Countries:
Belgium, France, Italy, Portugal, Slovenia, Spain, Switzerland, and the United Kingdom

EudraCT number: 2018-002180-25

ClinicalTrials.gov: NCT03762018



Rico Hunkeler (Clinical Trial Manager)

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ETOP IBCSG Partners Foundation

Effingerstrasse 33

3008 Bern, Switzerland